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Michael O Hottiger Selected Research

Cholesterol

1/2015The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.
6/2012ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation.

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Michael O Hottiger Research Topics

Disease

17Inflammation (Inflammations)
12/2020 - 10/2003
10Neoplasms (Cancer)
01/2023 - 02/2008
4Necrosis
01/2023 - 09/2006
4Hypoxia (Hypoxemia)
12/2020 - 09/2005
4Atherosclerosis
01/2020 - 04/2008
3Melanoma (Melanoma, Malignant)
12/2023 - 03/2009
3Genomic Instability
04/2009 - 01/2006
2Infections
02/2024 - 09/2011
2Colorectal Neoplasms (Colorectal Cancer)
12/2020 - 01/2014
2Ovarian Neoplasms (Ovarian Cancer)
01/2017 - 01/2015
1Renal Cell Carcinoma (Grawitz Tumor)
01/2023
1Breast Neoplasms (Breast Cancer)
01/2023
1Virus Diseases (Viral Diseases)
12/2022
1Systemic Inflammatory Response Syndrome (Sepsis Syndrome)
01/2021
1Colonic Neoplasms (Colon Cancer)
12/2020
1Heart Diseases (Heart Disease)
10/2020
1Whooping Cough (Pertussis)
10/2020
1Sepsis (Septicemia)
01/2019
1Bacterial Infections (Bacterial Infection)
01/2019
1Porcine Reproductive and Respiratory Syndrome (PRRS)
01/2019
1Leukemia
11/2018
1Hematologic Neoplasms (Hematological Malignancy)
11/2018
1Graft vs Host Disease (Graft-Versus-Host Disease)
11/2018
1Carcinoma (Carcinomatosis)
08/2016
1Starvation
08/2016
1Rett Syndrome (Rett's Disorder)
03/2016
1Neoplasm Metastasis (Metastasis)
08/2015
1Hearing Loss (Hearing Impairment)
11/2014
1Mitochondrial Diseases (Mitochondrial Disease)
11/2014
1Colitis
01/2014
1Back Pain (Backache)
08/2013
1Ischemia
08/2013
1Obesity
06/2012
1Glucose Intolerance
06/2012
1Metabolic Syndrome (Dysmetabolic Syndrome X)
06/2012
1Vascular Diseases (Vascular Disease)
11/2011
1Rheumatoid Arthritis
10/2011
1Osteoarthritis
10/2011
1Ataxia Telangiectasia (Louis Bar Syndrome)
09/2011
1Salmonella Infections (Salmonellosis)
08/2010
1Hyperplasia
07/2010
1Stomach Neoplasms (Stomach Cancer)
07/2010

Drug/Important Bio-Agent (IBA)

8Proteins (Proteins, Gene)FDA Link
12/2022 - 10/2003
6Poly(ADP-ribose) Polymerase InhibitorsIBA
12/2023 - 08/2013
6NF-kappa B (NF-kB)IBA
08/2010 - 10/2003
5ChromatinIBA
12/2023 - 01/2006
4Adenosine Diphosphate (ADP)IBA
01/2021 - 07/2010
4CytokinesIBA
01/2016 - 10/2011
4Transcription Factors (Transcription Factor)IBA
09/2015 - 01/2008
4Sirtuin 1IBA
01/2015 - 09/2010
3Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
08/2010 - 02/2008
2Adenosine Diphosphate Ribose (ADP-Ribose)IBA
01/2023 - 01/2021
2Oxygen (Dioxygen)IBA
12/2020 - 02/2008
2Interleukin-6 (Interleukin 6)IBA
10/2020 - 09/2015
2CholesterolIBA
01/2015 - 06/2012
2EnzymesIBA
01/2015 - 07/2010
2Small Interfering RNA (siRNA)IBA
10/2011 - 02/2008
2DNA (Deoxyribonucleic Acid)IBA
09/2011 - 01/2008
2Poly Adenosine Diphosphate RiboseIBA
01/2008 - 01/2008
11-oleoyl-2-stearoylphosphatidylcholineIBA
02/2024
1olaparibIBA
01/2023
1Nucleic AcidsIBA
12/2022
1TNF Receptor-Associated Factor 6 (TRAF6)IBA
12/2020
1Extracellular Matrix ProteinsIBA
12/2020
1Virulence Factors (Pathogenicity Factors)IBA
10/2020
1ponsinIBA
10/2020
12- ((7- nitrobenzo(c)(1,2,5)oxadiazol- 4- yl)thio)pyridine 1-oxideIBA
10/2020
1Insulin (Novolin)FDA Link
10/2020
1LipopolysaccharidesIBA
10/2020
1Pertussis ToxinIBA
10/2020
1NAD (NADH)IBA
01/2020
1SirtuinsIBA
01/2020
1LipidsIBA
01/2020
1Scavenger Receptors (Scavenger Receptor)IBA
01/2020
1Pattern Recognition ReceptorsIBA
01/2019
1Pathogen-Associated Molecular Pattern MoleculesIBA
01/2019
1ADP Ribose Transferases (ADP Ribosyltransferase)IBA
01/2019
1Interleukin-12 (IL 12)IBA
01/2019
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
11/2018
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2016
1Cyclin EIBA
08/2016
1CateninsIBA
01/2016
1InflammasomesIBA
01/2016
1InterferonsIBA
01/2016
1LDL CholesterolIBA
01/2015
1SRT3025IBA
01/2015
1Lactic Acid (Lactate)FDA LinkGeneric
11/2014
1TransferasesIBA
08/2013
1Glucose (Dextrose)FDA LinkGeneric
06/2012
1A 19IBA
06/2012
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2011
1LigandsIBA
10/2011
1Toll-Like Receptors (Toll-Like Receptor)IBA
10/2011
1InterleukinsIBA
10/2011
1Histones (Histone)IBA
09/2011
1Nuclear Proteins (Protein, Nuclear)IBA
08/2010
1N- (oxo- 5,6- dihydrophenanthridin- 2- yl)- N,N- dimethylacetamide hydrochlorideIBA
07/2010

Therapy/Procedure

2Therapeutics
12/2023 - 08/2015
1Ligation
12/2020
1Cell Transplantation
11/2018